Extracellular matrix roles during cardiac repair

Extracellular matrix scaffold for cardiac repair.

BACKGROUND Heart failure remains a significant problem. Tissue-engineered cardiac patches offer potential to treat severe heart failure. We studied an extracellular matrix scaffold for repairing the infarcted left ventricle. METHODS AND RESULTS Pigs (n=42) underwent left ventricular (LV) infarction. At 6 to 8 weeks, either 4-layer multilaminate urinary bladder-derived extracellular matrix or ...

Bioactive Extracellular Matrix Scaffold Promotes Adaptive Cardiac Remodeling and Repair

Extracellular Matrix Revisited: Roles in Tissue Engineering

[This corrects the article on p. S23 in vol. 20, PMID: 27230457.].

Reinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...

The Extracellular Matrix, Matrix Metalloproteinases and their roles in Disease

Biomedical research is often thought to primarily focus upon the trillions of cells that make up the body. However just as study of the immune system cannot ignore the lymph in favor of blood, the extracellular matrix (ECM) cannot be ignored in favor of the cells. The ECM is a dynamic structure that acts as scaffolding substrate for cell adhesion, as well as a reservoir of various proteins, gro...